N
eurons and neuronal networks decide, remember,
modulate, and control an animal’s every sensation, thought, movement, and
act. The intimate details of this network, including the dynamical properties
of individual and populations of neurons, give a nervous system the power
to control a wide array of behavioral functions. We want to know more about
neuronal dynamics and networks; about synaptic interactions between neurons;
about how neuronal signaling and behavior and control and environmental
stimuli are inextricably linked. Consequently, we have begun in a multi-university,
multi-disciplinary, multi-sponsor research program to integrate silicon
electronics with neurobiology. The compelling scientific reason for this
research is to correlate neuronal signaling and control with environmental
stimuli and behavior, to better understand the neural substrates of behavior.
With recent advances in ultralow mass and ultralow power electronics, we
are poised to develop implantable microcomputers capable of dynamically
interfacing with biological systems.
| Manduca Sexta |
Tritonia Diomedea |
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Our research effort comprises five main thrusts:
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Develop a standalone implantable microcomputer
that records from and stimulates neurons, sensory pathways, or motor control
pathways in an intact animal, using intracellular probes, extracellular
probes, or wire electrodes
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Develop miniaturized microelectromechanical
(MEMS) probes for recording intracellularly from neurons in untethered
animals
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Develop neurophysiological preparations and
techniques for implanting microchips and wire electrodes or MEMS probes
into or onto animals without damaging probes or tissue, including dealing
with issues of biocompatability
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Develop analytical models of the biology,
and experiments that software-test these models in behaving animals
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Reverse engineer winged flight and flight
control in a flying insect, and locomotion and escape bahavior in a marine
mollusc
Introduction
Faculty and Research Associates
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Chris
Diorio, Computer Science &
Engineering, University of Washington
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Thomas
Daniel, Zoology,
University of Washington
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Michael
Dickinson, Integrative Biology,
University of California, Berkeley
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Michael
Tu, Zoology,
University of Washington
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Mark
Willis, Biology, Case Western
Reserve University
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Karl
Böhringer, Electrical Engineering,
University of Washington
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Denice
Denton, College of Engineering,
University of Washington
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Dennis
Willows, Zoology,
University of Washington
Students and Postdoctoral Researchers
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Yael
Hannein, postdoctoral research, Electrical
Engineering, University of Washington
-
Russell Wyeth, graduate student,
Zoology,
University of Washington
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Jaideep
Mavoori, graduate student, Electrical Engineering,
University of Washington
Moth Movie #1
Moth Movie #2
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Jeremy Holleman, graduate student,
Electrical Engineering,
University of Washington
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Udo Lang, Masters student, graduated (date)
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Kevin Flick, graduate student, Zoology, University of Washington
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Katarzyna Kodziszewska, undergraduate student, Zoology, University of Washington
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Cody Montoya, undergraduate student, Zoology, University of Washington
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Nate Jacobson, undergraduate student, University of Washington
Sponsors
News and Press Releases
Publications
Research
Talks/Interviews/Presentations
Links
Industry
Support/Partners
Education in Implantable Electronics
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FHL Spring workshop 2001 --
Zoology 498
: Implantable Electrodes and Computers in Brain
Recent Status
Quote of the year:
"C slugs are, I'm sure, happy to die for the cause. Those C++ slugs are more
selfish-- they're object-oriented. There must exist a Sidney Carton slug,
squirming manfully to the guillotine: "it is a far, far better rest I go to than
I have ever known before." It could have hopes of Elysian fields dense in
seaweed and warm with tidal pools."
--- Anonymous