Treponema pallidum

Genes

T. pallidum protein NP_218463.1
human protein NP_001036.1 (serotonin)

Serotonin (5-hydroxytryptamine, or 5-HT) is derived from the amino acid tryptophan. It occurs in brain and intestinal tissue, platelets, and certain connective-tissue cells and is a component of many animal venoms (e.g., wasp, toad). A strong stimulator of blood- vessel constriction and a neurotransmitter, serotonin concentrates in certain brain areas, especially the midbrain and hypothalamus. Some cases of depression are apparently caused by reduced amounts or activity of serotonin in the brain; many antidepressants counteract that condition. Excessive brain serotonin activity may cause migraine headaches and nausea. LSD may act by inhibiting the action of serotonin2.

Alignment

 Score =  105 bits (262), Expect = 5e-23 
 Identities = 110/458 (24%), Positives = 184/458 (40%), Gaps = 75/458 (16%) 
 
Query: 8   RELFNSHVGVVLSCVGAAMGLANVWLFPGRLVEFGGVTFLIPYFIFLF--GLSRFGLMGE 65 
           RE +   V  +LS +G A+ L NVW FP    + GG  FL+PY I     G+  F +  E 
Sbjct: 79  RETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYM--E 136 
 
Query: 66  YAFGKTLRCGPVRAFTRVCETHPSCFLRALRGSGWFPVGVLLATCSFYVVIIGWILRYVV 125 
            A G+  R G +  + ++C           +G G+    +     S+Y  I+ W L Y++ 
Sbjct: 137 LALGQYHRNGCISIWRKICPI--------FKGIGYAICIIAFYIASYYNTIMAWALYYLI 188 
 
Query: 126 FSCTNALAGTQAHDLFYQVAGTSA----NVPWTLAA------------------------ 157 
            S T+ L  T   + +     T+     N+ WTL +                         
Sbjct: 189 SSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIHRSKGLQDL 248 
 
Query: 158 ----------IALTACVVSAGVQKGVERGNIIMMVLF---YGVLAFITGYIFTLPNAWIG 204 
                     I L   V+   + KGV+    ++ V     Y +L+ +     TLP AW G 
Sbjct: 249 GGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGATLPGAWRG 308 
 
Query: 205 MRRMLAFQSSSLCNPRLWLYALGMSFFSLSLGGAAMVLYGSYMPDTVDIPRTAFQTATLD 264 
           +   L      L    +W+ A    FFSL  G   ++ + SY     +  + A  T+ ++ 
Sbjct: 309 VLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVN 368 
 
Query: 265 FLASGMSALCLIP----SAWVLGMDVS-----SGPEFLFVTITRVASQIPMGVMISVLFF 315 
            + S +S   +       A +   DVS     +GP  LF+T     + +P     +++FF 
Sbjct: 369 CMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFF 428 
 
Query: 316 LCVLCAALSSAIAMLE----VILESFVHTCTVGRRTLTWSLALVVAF---VSLPLNAS-- 366 
           L ++   L S  A LE     +L+ F H     R     ++ +   F   V+L    +   
Sbjct: 429 LMLITLGLDSTFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSLVTLTFGGAYV 488 
 
Query: 367 MRVFETFTDIVVVILSPLSALMGSVMIFWVYG-AERCR 403 
           +++ E +     V+     AL+ +V + W YG  + CR 
Sbjct: 489 VKLLEEYATGPAVL---TVALIEAVAVSWFYGITQFCR 523