Halobacterium species NRC-1

Genes

Halobacterium species NRC-1 Protein - methylmalonyl-CoA decarboxylase, subunit alpha
Human Protein - propionyl Coenzyme A carboxylase, beta polypeptide [Homo sapiens]

My protein A - methylmalonyl-CoA decarboxylase, subunit alpha found in Halobacterium species NRC-1 is thought to aid in Lipid transport and metabolism. Protein B - propionyl Coenzyme A carboxylase, beta polypeptide found in humans aids in metabolism of amino acids and is a produced by the oxidation of fatty-acids. So at the very least we can happily conclude that both these proteins aid in the metabolic process. Next we notice the mention of Lipids and fatty-acids. I'm certainly not an expert in the field but I realize that the two are at least similar and having done a bit of research it appears that Lipids are synthesized from fatty-acids. This leads me to believe that it is entirely possible that the two share functions with regard specifically to fatty-acids and lipids but I was unable to find a reference confirming this hypothesis.

Alignment


Query: 2   TMEERIEDLREQTERALLGGGEARIESQHEKGKLTARERIDYFLDDGTFNELDQLRTHRS 61
           ++ ERIE+ R     ALLGGG+ RI++QH++GKLTARERI   LD G+F E D    HR 
Sbjct: 34  SVNERIENKRRT---ALLGGGQRRIDAQHKRGKLTARERISLLLDPGSFVESDMFVEHRC 90

Query: 62  TNFDM--DETKLPGDGVVTGYGDVNGRTTFVFAHDFTVFGGSLGEVFAEKVTKVMDRAME 119
            +F M  D+ K PGD VVTG G +NGR  +VF+ DFTVFGGSL    A+K+ K+MD+A+ 
Sbjct: 91  ADFGMAADKNKFPGDSVVTGRGRINGRLVYVFSQDFTVFGGSLSGAHAQKICKIMDQAIT 150

Query: 120 VGAPVVGLNDSAGARIQEGVDALGGFAEIFTRNEKASGVVPQISAIMGPCAGGAVYSPAI 179
           VGAPV+GLNDS GARIQEGV++L G+A+IF RN  ASGV+PQIS IMGPCAGGAVYSPA+
Sbjct: 151 VGAPVIGLNDSGGARIQEGVESLAGYADIFLRNVTASGVIPQISLIMGPCAGGAVYSPAL 210

Query: 180 TDFTVMVKDTSHMFITGPDVIETVTGEQVGFEELGGATTHAAESGVAHFACDSEEAALDN 239
           TDFT MVKDTS++FITGPDV+++VT E V  EELGGA TH   SGVAH A +++  AL N
Sbjct: 211 TDFTFMVKDTSYLFITGPDVVKSVTNEDVTQEELGGAKTHTTMSGVAHRAFENDVDALCN 270

Query: 240 IKRLLSYLPQNNVEDPPRVEPYDDP-ERRDDALETIVPDEPRKPYDMTDVVDSVVDEQSF 298
           ++   +YLP ++ +DP  V    DP +R    L+TIVP E  K Y+M D++ SVVDE+ F
Sbjct: 271 LRDFFNYLPLSS-QDPASVRECHDPSDRLVPELDTIVPLESTKAYNMVDIIHSVVDEREF 329

Query: 299 FEVQADYAKNIVVGFARLDGRSVGIVANQPRVNAGTLDIDASEKGSRFVRFCDSFNVPIL 358
           FE+  +YAKNI+VGFAR++GR+VGIV NQP+V +G LDI++S KG+RFVRFCD+FN+P++
Sbjct: 330 FEIMPNYAKNIIVGFARMNGRTVGIVGNQPKVASGCLDINSSVKGARFVRFCDAFNIPLI 389

Query: 359 TLVDVPGFLPGTDQEHGGIIRHGAKLLYAFSEASVPLMTVITRKAYGGAYDVMASKHIGA 418
           T VDVPGFLPGT QE+GGIIRHGAKLLYAF+EA+VP +TVITRKAYGGAYDVM+SKH+  
Sbjct: 390 TFVDVPGFLPGTAQEYGGIIRHGAKLLYAFAEATVPKVTVITRKAYGGAYDVMSSKHLCG 449

Query: 419 DVNYAWPTAEIAVMGPKGAVNVLYS--DELEAADDTAARRQELIDEYREEFANPYTAADR 476
           D NYAWPTAEIAVMG KGAV +++   + +EAA            EY E+FANP+ AA R
Sbjct: 450 DTNYAWPTAEIAVMGAKGAVEIIFKGHENVEAAQ----------AEYIEKFANPFPAAVR 499

Query: 477 GYLDAVIEPTETRPRLIDDLDMLASKREETPDKKHGNIPL 516
           G++D +I+P+ TR R+  DLD+LASK+ + P +KH NIPL
Sbjct: 500 GFVDDIIQPSSTRARICCDLDVLASKKVQRPWRKHANIPL 539