SET #2 - COG 0480 ================= PH1899 Organism: Pyrococcus horikoshii Protein ID: 14591642 Description: elongation factor 2 Noncoding upstream seq: 73 bp PAB0187 Organism: Pyrococcus abyssi Protein ID: 14520494 Description: translation elongation factor EF-2 Noncoding upstream seq: 80 bp MJ1048 Organism: Methanococcus jannaschii Protein ID: 15669237 Description: translation elongation factor EF-2 Noncoding upstream seq: 110 bp VNG2654Gm Organism: Halobacterium sp. NRC-1 Protein ID: 16554524 Description: Translation elongation factor 2 Noncoding upstream seq: 192 bp APE1432 Organism: Aeropyrum pernix Protein ID: 14601403 Description: elongation factor ef-2 Noncoding upstream seq: 50 bp Alignment Score 26913 CLUSTAL W (1.81) multiple sequence alignment PH1899 MVEMGRREEMIAKIKELMLQPERIRNIGIAAHIDHGKTTLSDNLLAGAGMISEELAGKQL PAB0187 ---MGRREEMIAKIKELMLQPERIRNIGIAAHIDHGKTTLSDNLLAGAGMISEELAGKQL MJ1048 ---MGKRAKMIAKIKELMEKYDRIRNIGICAHIDHGKTTLSDNLLAGAGMISKELAGEQL VNG2654Gm ---MGRRKKIVEQCERLMDNPEQIRNIAIAAHVDHGKTTLTDNLLAGAGMISEDTAGQQL APE1432 ---MGARVKVVSEIEKIMRNIDQIRNIGIIAHVDHGKTTTSDSLLAAAGIISERIAGEAL ** * ::: : :.:* : ::****.* **:****** :*.***.**:**: **: * PH1899 VLDFDEQEQARGITINAANVSMVHNYEGKDYLINLIDTPGHVDFGGDVTRAMRAIDGVII PAB0187 VLDFDEQEQARGITINAANVSMVHNYEGKDYLINLIDTPGHVDFGGDVTRAMRAIDGVII MJ1048 ALDFDEEEAQRGITIFAANVSMVHTYEGNEYLINLIDTPGHVDFGGDVTRAMRAIDGAIV VNG2654Gm AMDTEEDEQERGITIDAANVSMTHEYEGDDHLINLIDTPGHVDFGGDVTRAMRAVDGALV APE1432 VLDYLNVEKQRGITVKSANVSLYHEYEGKPYVINLIDTPGHVDFSGKVTRSLRVLDGAIV .:* : * ****: :****: * ***. ::************.*.***::*.:**.:: PH1899 VVDAVEGVMPQTETVVRQALREYVKPVLFINKVDRLIRELKLTPQQMMERFSKIIMDVNR PAB0187 VVDAVEGVMPQTETVVRQALREYVKPVLFINKVDRLIRELKLTPQQMMERFSKIIMDVNR MJ1048 VVCAVEGVMPQTETVLRQALRERVKPVLFINKVDRLINELKLTPEELQSRFIKIINDINN VNG2654Gm VVDAVEGAMPQTETVVRQALREGVKPTLFINKVDRLISELQEGPEEMQERLLSVIGDVNE APE1432 VVDAVEGVMTQTETVIRQALEERVRPILFINKVDRLIKELKLPPEKIQQRFVEIIKEVNN ** ****.*.*****:****.* *:* ********** **: *::: .*: .:* ::*. PH1899 LIQRYAP-EEYKKKWMVKVEDGSVAFGSAYYNWALSVPFMKRTGVKFNEIIDLTLKGD-- PAB0187 LIQRYAP-EEYKKQWMVKVEDGSVAFGSAYYNWALSVPFMKRTGVKFNEIIDLTLKGD-- MJ1048 LIRKMAP-EEFKDKWLVRVEDGSVAFGSAYNNWAISVPFMKKSGITFKDIIKYCEEDR-- VNG2654Gm LIRGMTEEKDDIEDWTVSVEDGTVAFGSALYKWGVSMPSMQRTGMDFGDIIDLERSDK-- APE1432 LIDLYAE-PEFRKKWKLDPNAGMVAFGSAKDKWGISVPQVKKKGITFREIIQAYEKGKEA ** : : ..* : : * ****** :*.:*:* :::.*: * :**. .. PH1899 NRTLRQKAPLHVVVLDMVVRHLPSPIEAQKYRIPHLWEGDISSDIGQAMLNCDPKGKMVM PAB0187 HKTLRQKAPLHVVVLDMVVKHLPNPIEAQKYRIPHLWQGDINSDVGQAMLNCDPKGKMVM MJ1048 QDELAEKAPLHEVVLDMVIKHLPSPPEAQKYRIPHLWKGDLNSEAGKAMLNCDPNGPLAG VNG2654Gm REELHEQTPLADVVLDMVAEHFPNPIDAQPRRIPTVWRGDADSEIAESMRLVDEDGEVVL APE1432 VAELSKKMPLHETLLDMVIKFVPNPREAQRYRIPKIWKGDINSEIGQAMLNADPDGPLVF * :: ** .:**** ...*.* :** *** :*.** .*: .::* * .* :. PH1899 VVTKIIIDKHAGEVATGRVWSGTVKSGQEVYLINTKRKARIQQVGIYMGPERINMEAVPA PAB0187 VVTKIIIDKHAGEVATGRVWSGTVKSGQEVYLINTKRKARIQQVGIYMGPERINMEAVPA MJ1048 VITKIIVDKHAGAVSVCRLFSGRIKQGDEVYMVNNQQKAKIQQVSVFMGPERIPVDSISA VNG2654Gm MVTDIGVDPHAGEIAAGRVFSGTLEKGQELYVSGTAGKNRVQSVGIYMGGEREEVDEVPA APE1432 FINDVRIEK-AGLVATGRVFSGTLRSGEEVYLLNAGKKSRLLQVSIYMGPFREVTKEIPA .:..: :: ** ::. *::** :..*:*:*: . * :: .*.::** * . :.* PH1899 GNIVAVTGLRDAMAGETVA----EEQIEPFEALHYVSEPVVTVAIEAKNVKDLPRLIEAL PAB0187 GNIVAVTGLRDAMAGETVA----EEPIEPFEALHYVSEPVVTVAIEAKNVKDLPRLIEAL MJ1048 GNICALVGLKEASAGETICSP--DKIIEPFEAITHISEPVITVAIEAKNTKDLPKLIEVL VNG2654Gm GNIAAVTGLKDAIAGSTVS----NEEMTPFESIDHISEPVITKSIEAQNMDDLPKLIETL APE1432 GNIGAVMGFEDVRAGETVVSLGYEENAAPFESLRYVSEPVVTIAVEPVKIQDLPKMIEAL *** *: *:.:. **.*: :: ***:: ::****:* ::*. : .***::**.* PH1899 RQLAKEDPTLHVKIDEETGQHLLSGMGELHLEVK-LYKLKKDWGIDIEVSEPIVVYRESI PAB0187 RQLAKEDPTLHVKIDEETGQHLLSGMGELHLEVK-LYKLKKDWGIDIDVSEPIVVYRESI MJ1048 RQVAREDPTVKVEINEETGEHLLSGMGELHIEIITKLKIERDAGIPVEVGQPIVVYRETV VNG2654Gm RQVSKEDPTISIEINEDTGEHLISGQGELHLEVQ-TQRIERNQGIPVTTGEPIVVYRETP APE1432 RKLTIEDPNLVVKINEETGEYLLSGMGPLHLEIA-LTMLREKFGVEVKASPPIVVYRETV *::: ***.: ::*:*:**::*:** * **:*: :... *: : .. *******: PH1899 TKSSPMVEGKSPNRHNRFYIVVEPMPDEIYNAIKEGIIP--EGRVKNPKEVAKKLAELGM PAB0187 TKPSPMVEGKSPNRHNRFYIVVEPMPDEIYNAIKEGIIP--EGRIKNPKEVAKKLAELGM MJ1048 TGQSPVVESKSPNKHNKLYFVVEPLEESVLQAYKEGRIPDVDTKRKLDDKIVQELIKAGM VNG2654Gm TSDSQEVEGVSPNRHNKFYITVEQLSDDVLEEIRLGEVS----MDMPEQERREVLQEAGM APE1432 RQQSRVFEGKSPNKHNKLYISVEPLNEETITLIQNGAVTE---DQDPKDRARILADKAGW * .*. ***:**::*: ** : :. : * :. .. : * PH1899 DYEIARGIVDIYN-GNMFIDNTKGVQYLNEVMDLLIDGFHQAMDEGPLAREPVMKVIVRL PAB0187 DYEIARGIVDVYN-GNMFLDNTKGVQYLNEVMDLLIDGFHQAMDEGPLAKEPVMKVIVRL MJ1048 DPEEAKRVMCIYE-GNVLINMTRGIVHLDEVKELIIQGFKEAMRNGPLAAEKCQGVKVKL VNG2654Gm DKETSQDVENIIG-RNIFIDDTKGIQHLNETMELVVDGLTDSLEDGPLAAEPVEGALIRL APE1432 DYNEARKIWAIDENINVFVDKTAGVQYLREVKDTIIAGFRLALKEGPLAAEPVRGVKVVL * : :: : : *:::: * *: :* *. : :: *: :: :**** * . : * PH1899 LDAQVHEDNVHRGPAQIYPAIRTAIHCAMMKSNPVLYEPYQKVIINIPYEYMGAVSREIT PAB0187 IDAQVHEDNVHRGPAQIYPAIRTAIHCAMMKSNPVLYEPYQKVIINIPYEYMGAVSREIT MJ1048 MDAVLHEDAIHRGPAQMIPAARFGIRDAMMQANPVLLEPMQFVYINTPQDFMGAAMREIS VNG2654Gm HDARLHEDAIHRGPAQVIPATRDAVHRALIDADIRLLEPIQDVRIDVPSEHMGAASGEVQ APE1432 HDAVIHEDPVHRGPGQLYPAVRNAIWAGILDGRPTLLEPLQKLDIRAPMEYLSNITAVLT ** :*** :****.*: ** * .: .::.. * ** * : * * :.:. : PH1899 QRRGQLVDMKQEGEVMTIIAEAPVAEMFGFAGSIRSATSGRALWSTEHAGFKRVPNELAQ PAB0187 QRRGQLVDMKQEGEVMTIIAEAPVAEMFGFAGAIRSATSGRALWSTEHAGFKRVPNELAQ MJ1048 NRRGQILDMEQEGDMAIIKAKCPVAEMFGFAGAIRGATQGRCLWSIEFAGYEKVPRDMQE VNG2654Gm GRRGRVDDMYQEGDLMVVEGIAPVDEMIGFSSDIRSATEGRASWNTENAGFRVMADNLQR APE1432 RKRGRIINVETTGVMARIIAAIPVAESFDLAGELRSATAGRAFWGVEFYGWAPVPDQMLQ :**:: :: * : : . ** * :.::. :*.** **. *. * *: :. :: . PH1899 QIIRQIRQRKGLDPNPPTEKDVCPLF PAB0187 QIIRQIRQRKGLDPNPPTEKDVCPLF MJ1048 QLIKQIRERKGLKLE----------- VNG2654Gm EIIMEIRERKGMKTELPESITHF--- APE1432 DLIAKIRQRKGLPPSPPKIDDLIGP- ::* :**:***: .