#2> COG0593 - Initiation of chromosome replication Protein ID Gene Org Length of upstream sequence 15805044 DR0002 Deinococcus Radiodurans 144 1904->3268 - 455 15612564 BH0001 Bacillus Halodurans 584 584->1933 + 450 16077069 BSU0001 Bacillus Subtilis 410 410->1750 + 447 15607143 RV0001 Mycobacterium tuberculosis 603 1->1524 + 508 15826866 ML0001 Mycobacterium leprae 550 1->1566 + 522 Rv0001 -------------------MTDDPGSGFTTVWNAVVSELNGDPKVDDGPSSDANLSAPLT ML0001 MFVPHAKKPEIYENQRDTSLADDLSLGFTTVWNAVVSELNGESNTDDEATNDSTLVTPLT BH0001 -------------------MEN-----IHDLWERALKSMEKKVSK--------------- BS_dnaA -------------------MEN-----ILDLWNQALAQIEKKLSK--------------- DR0002 --------------------------------------MRKNVSD--------------- :. . . Rv0001 PQQRAWLNLVQPLTIVEGFALLSVPSSFVQNEIERHLRAPITDALSRRLGHQIQLGVRIA ML0001 PQQRAWLNLVQPLTIIEGFALLSVPSSFVQNEIERHLRTPITDALSRRLGQQIQLGVRIA BH0001 PSFETWLKQTKANSIEDSTIIITAPNEFARDWLEKHYDELISETIDDLTG--VRLYPKFV BS_dnaA PSFETWMKSTKAHSLQGDTLTITAPNEFARDWLESRYLHLIADTIYELTG--EELSIKFV DR0002 LEYTTWFAPVKPLGVQEGSLLLGVRNSFTKDWFRDHYLELLLAALRSLGAEHPQVEFQVL . :*: .:. : . : . ..*.:: :. : : :: . .: :. Rv0001 PPATDEADDTTVPPSENPATTSPDTTTDNDEIDDSAAARGDNQHSWPSYFTERPHNTDSA ML0001 PPSTDHIDDN---SSSADVLLTDDCGTDTDENYG-EPLTGEYQG-LPTYFTERPHHTEST BH0001 IPTSQLDEPFVEQ-ELKKPMKQPPAQNG-----------------------EMPNN---- BS_dnaA IPQNQDVEDFMPKPQVKKAVKEDTS--------------------------DFPQN---- DR0002 PAAQDALLLPNDPPPAPEAAAPTPKTKAAPTPPP-----------------STPGDNR-- . : . * . Rv0001 TAGVTSLNRRYTFDTFVIGASNRFAHAAALAIAEAPARAYNPLFIWGESGLGKTHLLHAA ML0001 VTGGTSLNRRYTFETFVIGASNRFAHAAALAIAEAPARAYNPLFIWGESGLGKTHLLHAA BH0001 -----MLNDKYTFDTFVIGSGNRFAHAASLAVAEAPAKAYNPLFIYGGVGLGKTHLMHAI BS_dnaA -----MLNPKYTFDTFVIGSGNRFAHAASLAVAEAPAKAYNPLFIYGGVGLGKTHLMHAI DR0002 ----KTLNPKYTFENFVVGPNNNLAHAAALAVAESPGKAYNPLFIYGDVGLGKTHLMHAV ** :***:.**:*..*.:****:**:**:*.:*******:* *******:** Rv0001 GNYAQRLFPGMRVKYVSTEEFTNDFINSLRDDRKVAFKRSYRDVDVLLVDDIQFIEGKEG ML0001 GNYAQRLFPGMRVKYVSTEEFTNDFINSLRDDRKVAFKRSYRDVDVLLVDDIQFIEGKEG BH0001 GHYVMDHNPNAKVVYLSSEKFTNEFINAIRDNKAVNFRNKYRNVDVLLIDDIQFLAGKEQ BS_dnaA GHYVIDHNPSAKVVYLSSEKFTNEFINSIRDNKAVDFRNRYRNVDVLLIDDIQFLAGKEQ DR0002 GHYLAERFPEKRIEYVSTETFTNELINAIRDDKTTQFRNRYRSVDLLLVDDIQFLAGKER *:* * :: *:*:* ***::**::**:: . *:. **.**:**:*****: *** Rv0001 IQEEFFHTFNTLHNANKQIVISSDRPPKQLATLEDRLRTRFEWGLITDVQPPELETRIAI ML0001 IQEEFFHTFNTLHNANKQIVISSDRPPKQLATLEDRLRTRFEWGLITDVQPPELETRIAI BH0001 TQEEFFHTFNALHEDNKQIVISSDRPPKEIPTLEDRLRSRFEWGLITDITPPDLETRIAI BS_dnaA TQEEFFHTFNTLHEESKQIVISSDRPPKEIPTLEDRLRSRFEWGLITDITPPDLETRIAI DR0002 TQEEFFHTFNALYESNKQIILSSDRPPKDIQTLEGRLRSRFEWGLITDIQSPEYETRVAI *********:*:: .***::*******:: ***.***:*********: .*: ***:** Rv0001 LRKKAQMERLAVPDDVLELIASSIERNIRELEGALIRVTAFASLNKTPIDKALAEIVLRD ML0001 LRKKAQMERLAVPGDVLELIASSIERNIRELEGALIRVTAFASLNKTAIDKALAEIVLRD BH0001 LRKKAKAENLDIPNEVMLYIANQIDTNIRELEGALIRVVAYSSLINQDMNADLAAEALKD BS_dnaA LRKKAKAEGLDIPNEVMLYIANQIDSNIRELEGALIRVVAYSSLINKDINADLAAEALKD DR0002 LKMNAEQGHITIPQEVLELIARQVTSNIRELEGALMRVVAFASLNNVPFSRAAAAKALSN *: :*: : :* :*: ** .: *********:**.*::** : :. * .* : Rv0001 LIADANTMQISAATIMAATAEYFDTTVEELRGPGKTRALAQSRQIAMYLCRELTDLSLPK ML0001 LIADASTMQISAATIMTATAEYFDTTIEELRGPGKTRALAQSRQIAMYLCRELTDLSLPK BH0001 IIPNAKPRVLTITDIQKTVGEYFHVKLEDFKAKKRTKSVAFPRQIAMYLSRELTDASLPK BS_dnaA IIPSSKPKVITIKEIQRVVGQQFNIKLEDFKAKKRTKSVAFPRQIAMYLSREMTDSSLPK DR0002 VFAP-QEAKVEMTDVLRQVAAHYGTTPDLIRGSGRARDIVVPRQVAQYLIRALTDHSLPE ::. . : : .. : . : ::. ::: :. .**:* ** * :** ***: Rv0001 IGQAFG-RDHTTVMYAQRKILSEMAERREVFDHVKELTTRIRQRSKR----- ML0001 IGQAFG-RDHTTVMYAQRKILSEMAERREVFDHVKELTTRIRQRSKR----- BH0001 IGSEFGGRDHTTVIHAHEKISKLLSTDQELQDKIQDISDKLRS--------- BS_dnaA IGEEFGGRDHTTVIHAHEKISKLLADDEQLQQHVKEIKEQLK---------- DR0002 IGQFFG-RDHSTVMHAVSKITEQMGKDPELAATVNTLRNRIQGKEEEEEVGA **. ** ***:**::* ** . :. :: :: : :::