The PC-Algorithm, named after its inventors, Peter Sprites and Clark Glymour, is the gold standard for learning directed acyclic graphs (DAGs) from observational data. The algorithm was recently popularized by Kalisch and Bulhmann for learning sparse high-dimensional DAGs, containing many nodes, from smaller number of observations. However, the computational and sample complexity of the PC-Algorithm scale with the maximum degree of the network. The maximum degree grows with the number of nodes in many random graph families, including power-law graphs commonly observed in real-world networks. The algorithm is thus inappropriate for learning such networks. Moreover, the PC-Algorithm requires a stringent faithfulness assumption, which has been shown not to hold in high dimensions.
In this work, we exploit properties of large random graphs to show that DAGs can be learned by only conditioning on sets of small cardinality. In other words, for many graph families, we justify early stopping of PC-Algorithm’s search. While guaranteed to learn the skeleton of high-dimensional DAGs, this simple modification also turns out to greatly improve the computational and sample complexity of the PC-Algorithm. The new algorithm also requires a weaker faithfulness assumption and results in improved empirical performance in DAGs with hub nodes.

# Machine Learning

## Tuesday, May 9, 2017 - 12:00

## Revisiting the PC-Algorithm: How Much Conditioning Is Needed?

**Speaker:**Ali Shojaie

**Location:**CSE 305

## Tuesday, April 25, 2017 - 12:00

## Continuous State Machines and Grammars for Linguistic Structure Prediction

**Speaker:**Noah Smith

**Location:**CSE 305

Linguistic structure prediction infers abstract representations of text, like syntax trees and semantic graphs, enabling interpretation in applications like question answering, information extraction, and opinion analysis. This talk is about the latest family of methods for linguistic structure prediction, which make heavy use of representation learning via neural networks. I'll present these new methods as continuous generalizations of state machines and probabilistic grammars. I'll show how they've led to fast and accurate performance on several syntactic and semantic parsing problems.

## Tuesday, April 11, 2017 - 12:00

## Sequence Modeling: From Spectral Methods and Bayesian Nonparametrics to Deep Learning

**Speaker:**Alex Smola

**Location:**MOR 220

In this talk I will summarize a few recent developments in the design and analysis of sequence models. Starting with simple parametric models such as HMMs for sequences we look at nonparametric extensions in terms of their ability to model more fine-grained types of state and transition behavior. In particular we consider spectral embeddings, nonparametric Bayesian models such as the nested Chinese Restaurant Franchise and the Dirichlet-Hawkes Process. We conclude with a discussion of deep sequence models for user return time modeling, time-dependent collaborative filtering, and large-vocabulary user profiling.

## Tuesday, February 21, 2017 - 12:00

## Streaming Optimization Methods: Stochastic Gradient Descent, Momentum, and Newton's Method

**Speaker:**Sham Kakade

**Location:**CSE 305

Theory and practice differ widely in our more basic optimization
algorithms, such as stochastic gradient descent. For example, for the
practically relevant problem of setting parameters (such as learning
rates), principled methods are almost never used in practice. Can we
get a better a handle of the true behavior this widely used algorithm
(as opposed to worst case analysis)? Can we use these insights to
provide better algorithms?
This talk will survey recent work on this question. In particular, we
seek to understand how fast we can parallelize these algorithms using
simple averaging and mini-batching procedures. The talk will also
discuss ongoing work with regards to streaming methods for momentum
(i.e. acceleration), for implementing second order methods, and for
non-convex optimization.

## Tuesday, February 7, 2017 - 12:00

## Physics-based Visual Reasoning

**Speaker:**Roozbeh Mottaghi (AI2)

**Location:**CSE 305

Despite recent progress, AI is still far from understanding the physics of the world, and there is a large gap between the abilities of humans and the state-of-the-art methods. In this talk, I will focus on physics-based scene understanding and visual reasoning, which is a crucial next step in computer vision and AI.

Bio: Roozbeh Mottaghi is a Research Scientist at Allen Institute for Artificial Intelligence (AI2). Prior to joining AI2, he was a post-doctoral researcher at the Computer Science Department at Stanford University. He obtained his PhD in Computer Science in 2013 from University of California, Los Angeles. His research is mainly focused on computer vision and machine learning.

Bio: Roozbeh Mottaghi is a Research Scientist at Allen Institute for Artificial Intelligence (AI2). Prior to joining AI2, he was a post-doctoral researcher at the Computer Science Department at Stanford University. He obtained his PhD in Computer Science in 2013 from University of California, Los Angeles. His research is mainly focused on computer vision and machine learning.

## Tuesday, January 24, 2017 - 12:00

## Interactive and Interpretable Machine Learning Models for Human Machine Collaboration

**Speaker:**Been Kim (AI2)

**Location:**CSE 305

I envision a system that enables successful collaborations between humans and machine learning models by harnessing the relative strength to accomplish what neither can do alone. Machine learning techniques and humans have skills that complement each other --- machine learning techniques are good at computation on data at the lowest level of granularity, whereas people are better at abstracting knowledge from their experience, and transferring the knowledge across domains. The goal of my research is to develop a framework for human-in-the-loop machine learning that enables people to interact effectively with machine learning models to make better decisions using large datasets, without requiring in-depth knowledge about machine learning techniques.

In this talk, I present the Bayesian Case Model (BCM), a general framework for Bayesian case-based reasoning (CBR) and prototype classification and clustering. BCM brings the intuitive power of CBR to a Bayesian generative framework. The BCM learns prototypes, the “quintessential” observations that best represent clusters in a dataset, by performing joint inference on cluster labels, prototypes and important features. Simultaneously, BCM pursues sparsity by learning subspaces, the sets of features that play important roles in the characterization of the prototypes. The prototype and subspace representation provides quantitative benefits in interpretability while preserving classification accuracy. Human subject experiments verify statistically significant improvements to participants’ understanding when using explanations produced by BCM, compared to those given by prior art. I demonstrate the application of this model for an educational domain in which teachers cluster program

Bio: Been Kim is a Research Scientist at Allen Institute for Artificial Intelligence (AI2). She is also an affiliate faculty in the Department of Computer Science & Engineering at the University of Washington. Her research focuses on building interpretable machine learning. The vision of her research is to make humans empowered by machine learning, not overwhelmed by it. She received her PhD. from MIT. Prior to her PhD, she worked at the MathWorks as a software engineer.

In this talk, I present the Bayesian Case Model (BCM), a general framework for Bayesian case-based reasoning (CBR) and prototype classification and clustering. BCM brings the intuitive power of CBR to a Bayesian generative framework. The BCM learns prototypes, the “quintessential” observations that best represent clusters in a dataset, by performing joint inference on cluster labels, prototypes and important features. Simultaneously, BCM pursues sparsity by learning subspaces, the sets of features that play important roles in the characterization of the prototypes. The prototype and subspace representation provides quantitative benefits in interpretability while preserving classification accuracy. Human subject experiments verify statistically significant improvements to participants’ understanding when using explanations produced by BCM, compared to those given by prior art. I demonstrate the application of this model for an educational domain in which teachers cluster program

Bio: Been Kim is a Research Scientist at Allen Institute for Artificial Intelligence (AI2). She is also an affiliate faculty in the Department of Computer Science & Engineering at the University of Washington. Her research focuses on building interpretable machine learning. The vision of her research is to make humans empowered by machine learning, not overwhelmed by it. She received her PhD. from MIT. Prior to her PhD, she worked at the MathWorks as a software engineer.

## Friday, January 13, 2017 - 12:00

## Probabilistic programming: representations, inference, and applications to natural language

**Speaker:**Noah Goodman (Stanford)

**Location:**EEB 037

Probabilistic programing languages (PPLs) are formal languages for probabilistic modeling that describe complex distributions via programs with random choices. As a description language PPLs are a convenient and powerful way to construct models. I will show several examples drawn from cognitive science, focussing on language understanding: I will use a PPL to construct a model of language understanding as social reasoning; this model captures aspects of vague and figurative language. PPL implementations make it possible to separate inference algorithms from model representation by providing universal inference engines. Many techniques have been explored for inference, but they all struggle with efficiency for different model classes. Instead, we have been exploring systems that learn efficient inference strategies. I will discuss “deep amortized inference for PPLs”, a system that optimizes deep neural network “guide programs” to capture the implicit posterior distribution of a probabilistic program.

Bio: Noah Goodman is Associate Professor of Psychology, Computer Science (by courtesy), and Linguistics (by courtesy) at Stanford University. He studies the computational basis of natural and artificial intelligence, merging behavioral experiments with formal methods from statistics and programming languages. His research topics include language understanding, social reasoning, concept learning, probabilistic programming languages, and applications. ProfessorGoodman received his Ph.D. in mathematics from the University of Texas at Austin in 2003. In 2005 he entered cognitive science, working as Postdoc and Research Scientist at MIT. In 2010 he moved to Stanford where he runs the Computation and Cognition Lab. Professor Goodmanhas published more than 150 papers in fields including psychology, linguistics, computer science, and mathematics. His work has been recognized by the James S. McDonnell Foundation Scholar Award, the Roger N. Shepard Distinguished Visiting Scholar Award, the Alfred P. Sloan Research Fellowship in Neuroscience, and six computational modeling prizes from the Cognitive Science Society. He is Fellow of the Uber AI Labs, Academic Co-Founder and Advisor of Gamalon Labs, and advisor to several other start-ups.

Bio: Noah Goodman is Associate Professor of Psychology, Computer Science (by courtesy), and Linguistics (by courtesy) at Stanford University. He studies the computational basis of natural and artificial intelligence, merging behavioral experiments with formal methods from statistics and programming languages. His research topics include language understanding, social reasoning, concept learning, probabilistic programming languages, and applications. ProfessorGoodman received his Ph.D. in mathematics from the University of Texas at Austin in 2003. In 2005 he entered cognitive science, working as Postdoc and Research Scientist at MIT. In 2010 he moved to Stanford where he runs the Computation and Cognition Lab. Professor Goodmanhas published more than 150 papers in fields including psychology, linguistics, computer science, and mathematics. His work has been recognized by the James S. McDonnell Foundation Scholar Award, the Roger N. Shepard Distinguished Visiting Scholar Award, the Alfred P. Sloan Research Fellowship in Neuroscience, and six computational modeling prizes from the Cognitive Science Society. He is Fellow of the Uber AI Labs, Academic Co-Founder and Advisor of Gamalon Labs, and advisor to several other start-ups.

## Tuesday, November 29, 2016 - 12:00

## Computational and Statistical Issues in Genomics

**Speaker:**David Heckerman (MSR)

**Location:**CSE 305

In the last decade, genomics has seen an explosion in the production of data due to the decreasing costs and processing times associated with DNA sequencing. I will discuss how the cloud as well as techniques from mathematics and computer science help take advantage of this big data. My discussion will include linear mixed models, a popular model for association studies. I will show how these models work well and, if there is time, talk about why they do.

## Tuesday, November 15, 2016 - 12:00

## Sparse Additive Modeling

**Speaker:**Noah Simon (Statistics)

**Location:**CSE 305

Our ability to collect data has exploded over recent years. Across science, we now collect thousands of measurements on each person. One of the most common tasks of interest is to use these measurements to predict some response. Prediction methods must balance 3 objectives: predictive performance, computational tractability, and, in many applications, interpretability. In this talk we will discuss a broad class of models which effectively balance these objectives: Sparse additive models induced by combining a structural semi-norm and sparsity penalty. These are more flexible than the standard linear penalized model, but maintain its interpretability and computational tractability. We will show when these penalties can and cannot be combined to induce the desired structure and sparsity. We will give an efficient algorithm for fitting a wide class of these models. We will also discuss a particular type of structural penalty (hierarchical sparsity) which has additional nice behaviour. We will consider an application: Predicting disease phenotype in inflammatory bowel disease from gene expression measurements. Time permitting, we will additionally touch on the theoretical properties of these sparse additive estimators.

## Tuesday, November 1, 2016 - 12:00

## Develop the Curing AI for Precision Medicine

**Speaker:**Hoifung Poon (MSR)

**Location:**CSE 305

Medicine today is imprecise. For the top 20 prescription drugs in the U.S., 80% of patients are non-responders. Recent disruptions in sensor technology have enabled precise categorization of diseases and treatment effects, with the $1000 human genome being a prime example. However, progress in precision medicine is difficult, as large-scale knowledge and reasoning become the ultimate bottlenecks in deciphering cancer and other complex diseases. Today, it takes hours for a molecular tumor board of many specialists to review one patient’s omics data and make treatment decisions. With 1.6 million new cancer cases and 600 thousand deaths in the U.S. each year, this is clearly not scalable. In this talk, I'll present Project Hanover and our latest efforts in advancing machine reading and predictive analytics for personalized cancer treatment and chronic disease management.