TitleThe aptamer core of SAM-IV riboswitches mimics the ligand-binding site of SAM-I riboswitches.
Publication TypeJournal Article
Year of Publication2008
AuthorsWeinberg Z, Regulski EE, Hammond MC, Barrick JE, Yao Z, Ruzzo WL, Breaker RR
JournalRNA (New York, N.Y.)
Date or Month Published2008 May
KeywordsAptamers, Nucleotide, Base Sequence, Binding Sites, DNA Primers, Evolution, Molecular, Ligands, Nucleic Acid Conformation, RNA, Bacterial, RNA, Messenger, S-Adenosylmethionine, Streptomyces coelicolor
AbstractA novel family of riboswitches, called SAM-IV, is the fourth distinct set of mRNA elements to be reported that regulate gene expression via direct sensing of S-adenosylmethionine (SAM or AdoMet). SAM-IV riboswitches share conserved nucleotide positions with the previously described SAM-I riboswitches, despite rearranged structures and nucleotide positions with family-specific nucleotide identities. Sequence analysis and molecular recognition experiments suggest that SAM-I and SAM-IV riboswitches share similar ligand binding sites, but have different scaffolds. Our findings support the view that RNA has considerable structural versatility and reveal that riboswitches exploit this potential to expand the scope of RNA in genetic regulation.
Downloadshttp://www.ncbi.nlm.nih.gov/pubmed/18369181?dopt=Abstract Abstract
Alternate JournalRNA
Citation Key1870
PubMed ID18369181